Session: Neuroinfections and Neuroinflammation

Neuroinfections and Neuroinflammation

Description:

Neuroinflammation may be a complex inflammatory process within the central systema nervosum which is sought to play a crucial defensive role against various pathogens, toxins or factors that induce neurodegeneration. The onset of neurodegenerative diseases and various microbial infections are counted as stimuli which will challenge the host system and trigger the event of neuroinflammation. The homeostatic nature of neuroinflammation is important to take care of the neuroplasticity. Neuroinflammation is regulated by the activity of neuronal, glial, and endothelial cells within the neurovascular unit, which is a “platform” for the coordinated action of pro- and anti-inflammatory mechanisms. Production of inflammatory mediators (cytokines, chemokines, reactive oxygen species) by brain resident cells or cells migrating from the peripheral blood, leads to the impairment of barrier integrity, thereby further affecting the course of local inflammation.