We hypothesize a two-way street for the role setting events may play in autism treatment and recovery. Historically, therapy choice has remained on one side of the street or the other - without recognizing the separate potential of biological and behavioral setting events or combining these approaches into a synergistic model. Biological events such as change in diet or probiotics may first open the door for environmental interventions such as Applied Behavioral Analysis - ABA- if we "till the soil (produce healthful change in the microbiome) BEFORE we plant the seeds" (introduce behavioral or other environmental modification). Environmental modifications may similarly unlock bioaccessibility/utilization of nutrients for biological interventions. Introducing both biological and behavioral modifications in combination may certainly be the best option. Giving the body all critical resources at our disposal and then trusting the body to make optimal use of them is indeed worth consideration and further study.