Neuroscience conference 2022

Natalia Beloborodova

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Russian Federation

Title: The effect of microbial metabolites on the outcome of the consequences of brain damage

Abstract

Patients who have experienced severe brain damage (for example, traumatic brain injury, cerebral circulatory disorders, neurosurgical surgery, etc.) do not always fully recover after an acute episode of the disease; they often develop a chronic critical state (CCS) when they need intensive therapy for a long time. In order to improve the prognosis, studies of the "microbiota-gut-brain" relationship are being conducted. In our study, taxonomic disorders characteristic of CCS were identified, as well as the peculiarities of the interaction of a critically ill organism with its microbiota at the metabolic level were studied. It has been shown that monitoring of microbial metabolites circulating in the blood makes it possible to assess the degree of dysfunction of the gut microbiota. A close relationship has been established between the level of microbial metabolites and the outcome of the disease in the most severe neurological patients in CCS.

Biography

Natalia V. Beloborodova was educated at the Pirogov Russian National Research Medical University, and a specialization in Clinical Microbiology. She has been a Professor since 1996. Recently she is the Head of the Laboratory of metabolism in critical state. She is the author of more than 500 scientific publications, including articles, book chapters, monographs, patents, etc. In 2021, she was awarded the title of Honored Scientist of the Russian Federation.