Virtual Conference
Neuroscience conference 2022

Carmen M Terzic

Mayo Clinic, USA

Title: Treatment of functional movement disorders: The best approach


Functional movement disorder (FMD) is a subtype of functional neurologic symptom disorder in which the presenting symptom may be tremor, dystonia, weakness, gait disorder, or other abnormal movement. Functional movement disorders are increasingly being diagnosed secondary to awareness of this condition. Behavioral Shaping Therapy (BeST) is a rehabilitative/retraining, goal-oriented program with intensive physical and occupational therapy developed to treat functional movement disorders. 

This is an outpatient rehabilitation program based on the concept of motor-reprogramming and it is provided to appropriate patients following a comprehensive, diagnostic neurological evaluation, including psychiatric/psychological assessment. 

Therapeutic interventions include diaphragmatic breathing, muscle relaxation techniques, purposeful motor tasks, stop and reset, body scanning, proprioception training, among others.  These strategies serve to interrupt maladaptive motor habits and habituate normal muscle control for correcting gait abnormalities and reducing extraneous movements.

In this presentation, we will discuss functional movement disorders and the BeST program including, comprehensive evaluation and diagnosis, program structure, participation criteria, role of physiatrist, physical, occupational and speech therapy, specific interventions and follow up, and patients outcomes.  


The research efforts of Carmen M. Terzic, M.D., Ph.D., and her team attempt to direct stem cells toward cardiogenesis, to assess the role of nuclear transport during stem cell differentiation and to optimize their properties for cardiac commitment. Dr. Terzic's work includes developing techniques by which direct injection of stem cells in a murine model of cardiac infarction engrafts and repopulates the diseased heart with cardiac cells derived from the stem cells. The ultimate goal is to establish cardiovascular regenerative medicine as the new therapeutic modality for heart disease.

Dr. Terzic and her team have evaluated the cardiogenic potential of stem cells among patients. Together with Mayo Clinic's Cardiovascular Health Clinic, Department of Physical Medicine and Rehabilitation, and Cardiovascular Research Laboratory, Dr. Terzic has explored the individual variation in the number of circulating progenitor cells and the correlation between the cardiogenic potential of circulating progenitor cells and cardiovascular disease risk factors, risk indicators and clinical outcome after a cardiovascular event. The goal of this research is to introduce stem cell science into the innovative practice of prophylactic medicine in order to advance personalized wellness.