Aastha Vats

Lady Hardinge Medical College, India

Title: Treatment of patients with schizophrenia and comorbid chronic hepatitis with paliperidone: A systematic review


Schizophrenia is a severe mental disorder and antipsychotics are drugs usually used to treat this condition. Chronic hepatitis is a condition that can significantly impair hepatic functions. Most antipsychotics are metabolized by the liver, except for paliperidone, which undergoes the least amount of hepatic metabolism. This systematic review was conducted to investigate paliperidone's effectiveness and safety in patients with schizophrenia and concurrent chronic hepatitis. A detailed search using two databases, PubMed and Google Scholar, was done from June 2022 to July 2022. The PubMed search yielded 443 results and three more results were identified from Google Scholar. After a thorough screening, seven results pertinent to our study were taken into consideration for this review. All of the studies suggested that paliperidone is a safe and effective drug for the treatment of schizophrenia and since it does not undergo major hepatic metabolism and has no drug-drug interactions with antiviral drugs given in the treatment of chronic hepatitis, It can be safely used to treat schizophrenia with chronic hepatitis as a comorbid condition.


Aastha Vats graduated from Lady Hardinge Medical College, New Delhi in 2020. Curently she is working as a Medical Officer at an NGO that provides in-patient and out-patient services to adults and juveniles with substance abuse disorders. She has published about 5 articles in this very short span since she began her career. She wishes to contribute more to the society and make suitable amends in the treatment modality of various disorders that can be life changing for the patients.